At Profil, we investigate both semi-invasive and non-invasive continuous glucose monitors (CGM). Semi-invasive CGM assesses glucose under the skin via a catheter inserted through a skin perforation. Non-invasive CGM leaves the skin intact. We have extensive experience in assessing the accuracy of novel CGM devices.
We have extensive experience in assessing the accuracy of novel CGM devices, both in healthy volunteers and people with type 1 or type 2 diabetes.
The most widely used metric is Mean Absolute Relative Difference versus the reference glucose measurements. Accepted graphic displays include the Clark and Consensus Error Grids.
Adequate hyperglycemic glucose excursions can be assured by an OGTT or MMTT, with omission/delay of mealtime insulin in people treated with insulin treated diabetes.
A frequent error is insufficient assessment of CGM accuracy in the hypoglycemic range. A hypoglycemic clamp allows for safe and controlled collection of an adequate number of samples in the hypoglycemic range.
References: PMID: 37102600
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